In human breast cancer, the assessment of CA 15-3 (Darlix et al., 2016; Di Gioia et al., 2016; Shao et al., 2015), CRP (Allin and Nordestgaard, 2011; Han et al., 2011; Shimura et al., 2019), and LDH (Huang et al., 2016; Koukourakis et al., 2009; Naik and Decock, 2020) has been well described and correlated with prognostic factors and overall survival of patients. The gene discussed is CRP; the disease is breast cancer.