RCT, randomized controlled trial; CV, cardiovascular; CVD, cardiovascular disease; MI, myocardial infarction; HFrEF, heart failure with reduced ejection fraction; LVEF, left ventricular ejection fraction; HF, heart failure; ICD, implantable cardioverter-defibrillator; MACE, main adverse cardiac event; HbA1c, hemoglobin A1c; NYHA, New York Heart Association; NT-proBNP, N-terminal pro-B-type natriuretic peptide. The gene discussed is NPPB; the disease is hydrops fetalis.