Unmonitored use of corticosteroids in COVID-19 treatment and DM leads to an increased susceptibility to contracting mucormycosis due to an interplay of factors causing immunosuppression and hyperglycemia through (I) defective phagocytic mechanism; (II) upregulation of GRP78 receptors in humans and CotH (Mucorales specific protein) in the fungi (entry into human endothelial cells by fungus is facilitated by the interaction of GRP78 and CotH); (III) hyperglycation of iron sequestering proteins causing increased iron delivery to the Mucorales that is essential for their growth [1,15,16]. This evidence concerns the gene HSPA5 and COVID-19.