CASP1 and bacterial infectious disease: In this study, the KJ-34-secreted antibiotic metabolites identified by untargeted metabolome included ac-yvad-cho, benzoylstaurosporine, TAXOL C, trichostatin A, thapsigargin, kabiramide B, scopolamine, enniatin B, latrunculin A, rifaximin, rigin, and garcinone C. Ac-YVAD-CHO is a caspase-1 inhibitor that suppresses bacterial infections by mediating ATP release (Xiang et al., 2013).