HIF1A and heart failure: HIF1A was significantly associated with pneumonia (Inference Score: 161.07), inflammation (Inference Score: 467.34), and necrosis (Inference Score: 536.32), and was highly associated with certain cardiovascular diseases, including heart failure (Inference Score: 118.29), cardiomegaly (Inference Score: 190.62), and cardiomyopathies (Inference Score: 200.80) (Figure 7A).