PDCD4 and endothelial dysfunction: The antihypertensive tripeptide Leu-Ser-Trp (LSW) could increase miRNA-145 loading in VSMC-derived EVs and attenuated ox-LDL-induced endothelial dysfunction via miRNA-145 delivery, which was internalized into ECs and downregulated PDCD4 (programmed cell death protein 4) expression (132).