However, a proangiogenic effect of 11,12-EET and 14,15-EET, the main EET regioisomers in mammals (Spector and Kim, 2015), has been described via the epidermal growth factor (EGF) and VEGF pathways (Zhang et al., 2014), which may explain the finding that EETs promote tumor growth. This evidence concerns the gene EGF and neoplasm.