EPHX2 and neoplasm: The role of epoxidized LC-PUFAs is well established in several biological processes, such as angiogenesis, inflammation, and tumor growth: In different animal models, it has been shown that sEH-inhibition has a positive influence on cardiovascular and liver abnormalities (Iyer et al., 2012), liver fibrosis and portal hypertension (Zhang et al., 2018), fatty liver (Yao et al., 2019) and non-alcoholic steatohepatitis (Wang et al., 2019).