TGFB1 and renal fibrosis: Notably, TGF-β1 is a potent fibrogenic factor that can mediate EMT through the regulatory effects of HMGA2 (Hills and Squires, 2010; Iwano, 2010; Wang et al., 2016)and mediate the development of renal fibrosis through different signaling pathways (Hills and Squires, 2010; Iwano, 2010).