Activation of DOR with its specific agonist UFP-512 substantially decreased BACE1 expression and its activity in a highly differentiated rat PC-12 cell line with imitated AD injury, whereas DOR antagonism with naltrindole reversed the UFP-512 effects while causing an enhancement of BACE1 expression and activity along with Aβ42 production under physiological conditions (Antonino et al., 2022). This evidence concerns the gene BACE1 and Alzheimer disease.