Importantly, neither activation of DOR in vitro nor blockage of DOR in vivo affected the processing of Notch, N-cadherin, or APLP-1 by either BACE1 or γ-secretase, thus providing direct evidence that antagonism of DOR specifically blocks the amyloidogenic pathway and efficaciously prevents AD progression in mice (Teng et al., 2010). This evidence concerns the gene BACE1 and Alzheimer disease.