PLA2G7 and familial pancreatic carcinoma: Freire et al. (2020) reported that variants in cachexia-inducible factors and their associated regulatory genes had the highest frequency in pancreatic cancer patients, and the expression levels of key cachexia genes had predictive prognostic value in pancreatic cancer. Meanwhile, specifically targeting PLA2G7 can alleviate cachexia levels in tumor-bearing mice (Morigny et al., 2021).