Downregulation or inhibition of TLR4 has been shown to reduce angiotensin II-induced VSMC migration and proliferation (De Batista et al., 2014; Qi et al., 2021), and this would contribute to explain the beneficial effects of TLR4 blockade in vascular remodelling and mechanical alterations observed in hypertension (Hernanz et al., 2015). The gene discussed is AGT; the disease is Hypertension.