Several reports suggest that IL-1β levels are increased in patients with CVDs such as hypertension and atherosclerosis, where this cytokine participates in the vascular proinflammatory and oxidative responses (Krishnan et al., 2014; Pfeiler et al., 2019; Mai and Liao, 2020; Melton and Qiu, 2021; Silveira Rossi et al., 2022). The gene discussed is IL1B; the disease is atherosclerosis.