CYCS and breast cancer: Ma et al. (2017) reported that BBR prevents the proliferation and migration of breast cancer ZR-75-30 cells by regulating ephrin-B2. BBR also increases chemosensitivity, reverses hypoxia-induced chemoresistance, and further induces apoptosis in breast cancer (Pan et al., 2017b; Pan et al., 2017c). Moreover, Zhao et al. (2017) reported that BBR inhibits triple-negative breast cancer. BBR induces caspase-9/cytochrome c-mediated apoptosis both in vitro and in vivo to inhibit the proliferation of TNBC cells.