To better understand whether the network measures derived from tau PET images are primarily driven by specific tau binding rather than non-specific signal which would resemble more of structural MR data, we applied the same approach to construct individual level gray matter and white matter networks based on tissue density map derived from T1w-MRI, and subsequently evaluated these T1w-MRI derived network measures in their ability to differentiate AD diagnostic groups and their association with cognition (Supplementary Tables 5–7). This evidence concerns the gene MAPT and Alzheimer disease.