MAPK1 and RASopathy: Among the PAK-activated pathways, mentions should be made of the MAP kinase ERK pathways, the alteration of which leads to RASopathies, the Akt-PI3Kinase-mTor and Wnt pathways involved in ASD, the NF-κB pathway involved in apoptosis, among others (Yao et al., 2020; Caracci et al., 2021; Sharma and Mehan, 2021; Tartaglia et al., 2022).