CFL1 and Alzheimer disease: In post-mortem brains of Alzheimer’s disease (AD) patients, PAK proteins are markedly reduced and their phosphorylated forms present abnormal localization, which is also correlated with abnormal cofilin activation and aggregates in neurites (Ma et al., 2008; Arsenault et al., 2013; Bories et al., 2017; Lauterborn et al., 2020).