MAPT and Alzheimer disease: Recent studies have shown that, compared with Aβ, the aggregation of p-Tau is more closely related to the decline of early cognitive function and disease progression of AD (Spires-Jones and Hyman, 2014; Ossenkoppele et al., 2019), which may be an important starting factor for early memory decline, dementia and other symptoms and promote disease progression (Brier et al., 2016).