MAPT and Alzheimer disease: The accumulation of p-Tau can reportedly disrupt the stability of the microtubule structure, leading to the destruction of the synaptic structure of neurons in the brain and the interruption of material and signal transmission until the death of neuron cells, which is considered to be the main pathological feature of neurodegenerative diseases such as Alzheimer’s disease (AD) (Congdon and Sigurdsson, 2018).