Unlike in adult mice, the cascade of brain mitochondria-ATP-Nuak1-Tau has been documented in newborn rats, which may be a potential mechanism of age-dependent tau phosphorylation at Ser202, Ser356 and Thr205 and cognitive impairment after sevoflurane anesthesia in mice (Yu et al., 2020). Here, NUAK1 is linked to Cognitive impairment.