This phenomenon can be explained in the following ways: In addition to inducing tau phosphorylation, dexmedetomidine can induce apoptosis in rodents (Liu et al., 2016), which can reduce neuroinflammation and cognitive impairment in adult mice induced by high molecular group box 1 (HMGB1) and surgery (Hu et al., 2018). Here, MAPT is linked to Cognitive impairment.