MAPT and Alzheimer disease: More than 40 phosphorylation sites of Ser/Thr have been identified in the tau protein of AD, such as Thr181, Ser198, Ser199, Ser202, Thr205, Thr212, Ser214, Thr217, Thr231, Ser235, Ser262, Ser356, Ser396, Thr403, Ser404 and Ser422 (Wang et al., 2013; Kimura et al., 2018).