CRP and Menkes disease: Additionally, CRP as an index of inflammation has been associated with several aspects of MD such as risk for antidepressant resistance, increased risk for psychiatric hospitalization, increased risk for number of depressive symptoms, and an increased risk to experience psychosocial difficulties due to depressive symptoms (Haroon et al., 2018; Köhler-Forsberg et al., 2017; O'Shields and Mowbray, 2021; Wium-Andersen et al., 2013).