Interestingly, clock-like signatures SBS1 (due to the spontaneous deamination of mCpGs) and SBS5 (unknown etiology, age-related) were significantly enriched in splice mutations of several cancer types (P < 6e−3, Wilcoxon rank-sum test), including esophageal, stomach and colorectal cancers (Figure 4B). The gene discussed is CLOCK; the disease is colorectal cancer.