The scores of target binding to MAPK3 for the 8 miRNAs screened are depicted in Supplementary Table 2, among which miR-4270, miR-92a-2-5p, miR-423-5p, and miR-613 ranked at the top and all participated in T2DM or vascular injury [26–29]. The gene discussed is MAPK3; the disease is type 2 diabetes mellitus.