Initially, we screened out 37 candidate DEGs associated with vascular damage in T2DM through differential analysis of T2DM-associated datasets GSE15653 and GSE21340, among which Alb, MAPK3, MAPK1, Hras, and Nras were the top five genes ranked by the degree value in the PPI network. Here, MAPK1 is linked to type 2 diabetes mellitus.