Furthermore, clinic sample detection showed that circ_0020316 and KCNQ1OT1 expressions were high in the peripheral bloods of T2DM patients, and dual luciferase gene reporter assay documented that circ_0020316 and KCNQ1OT1 bound to miR-92a-2-5p. This evidence concerns the gene KCNQ1OT1 and type 2 diabetes mellitus.