Considering this, this research was conducted through bioinformatics analysis and experiments on peripheral blood from T2DM patients and revealed that KCNQ1OT1/circ_0020316-miR-92a-2-5p-MAPK3 regulatory networks might promote vascular injury in T2DM. The gene discussed is KCNQ1OT1; the disease is type 2 diabetes mellitus.