Adding pTau181 to a logistic regression model with age, sex, and APOE increased the AUCs for differentiating between AD and OND from 0.79 (CI: 0.71–0.86) to 0.84 (0.77–0.91; p < 0.001) while adding tTau, NfL, or GFAP resulted in a marginally increased AUC of 0.80–0.81 (Figure 4, Table 4). Here, GFAP is linked to Alzheimer disease.