SELP and Menorrhagia: The appearance of early menorrhagia in the availability of the genetic "favorable" and background initiating factor leads to endothelium dysfunction and damage to the vessel wall, followed by the release of von Willebrand factor and P-selectin into the blood, the latter triggering a cascade of the hemostasis system: recognition of damage to the endothelial wall, adhesion and aggregation of blood platelets.