UBE2C has been described as a hub gene of PCa i.e., a gene with high connectivity in the genetic interaction network and is involved in many oncogenic pathways involved in PCa progression such as NOTCH signalling and WNT-β-Catenin signalling (71), while also being positively correlated with the progression of other cancers types such as breast and ovarian, whereby its activity promotes a more aggressive tumour phenotype (73, 74). The gene discussed is UBE2C; the disease is posterior cortical atrophy.