Downregulating FAP-α with siRNA in SKOV3 cells inhibited ovarian tumor growth in nude mice (15) whereas FAP-α overexpression in SKOV3 cells promoted ovarian cancer cell proliferation, drug resistance, invasiveness and migration in vitro, and tumor growth in vivo (BALB/c-nu/nu mice) (16). The gene discussed is FAP; the disease is ovarian neoplasm.