Five of these NF2 meningiomas (N2, N4, N5, N9, and N10) had additional cytogenetic changes, including loss of the short arm of chromosome 1 (chr1p), while the other five (N1, N3, N6, N7, and N8) displayed no significant chromosomal instability aside from chr22q monosomy. Here, NF2 is linked to meningioma.