The ten non-NF2 meningiomas had missense mutations in TRAF7. Five of these TRAF7-altered meningiomas also contained an E17K mutation in AKT1 (AKT1E17K), while the other five TRAF7-altered tumors carried additional K409Q mutation in KLF4 (KLF4K409Q). This evidence concerns the gene TRAF7 and meningioma.