SPOP and prostate neoplasm: Moreover, TCGA, which profiled DNA methylation levels of over 300 prostate tumor tissues using Illumina HM450 arrays, revealed heterogeneous DNA methylation patterns amongst 8 prostate tumor molecular subtypes including: TMPRSS2-ERG fusion, TMPRSS2-ETV1 fusion, TMPRSS2-ETV4 fusion, TMPRSS2-FLI1 fusion, SPOP mutation, FOXA1 mutation, IDH1 mutation, and tumors without genetic alterations (47).