P62 (a stress-induced adaptor protein) inhibits ubiquitination, promotes ferroylation, and suppresses the expression of SLC7A11 in p53-mutant (MT) GBM, whereas it weakens ferroylation and increases SLC7A11 expression in p53-wild-type (WT) GBM (21). This evidence concerns the gene TP53 and glioblastoma.