Interestingly, ferroptosis exhibits immunogenicity in vitro and in vivo, triggering a vaccination-like effect in immunocompetent mice, in which ATP and high mobility group box 1 (HMGB1), the most typical injury-related molecular patterns associated with immunogenic cell death, can be passively released and act as immunogenic signals that affect the immunogenicity of early ferroptotic cancer cells (84). The gene discussed is HMGB1; the disease is cancer.