Using LASSO regression, we built a prognostic model in the TCGA-HCC cohort, which included ten mitophagy-related genes (G6PD, KIF20A, SLC1A5, TPX2, ANXA10, TRNP1, ADH4, CYP2C9, CFHR3, and SPP1). This evidence concerns the gene SPP1 and hepatocellular carcinoma.