As shown in the heat map (Figure 6C), compared with normal tissues, G6PD, KIF20A, SLC1A5, TPX2, TRNP1 and SPP1 are significantly up-regulated in HCC, while ANXA10, ADH4, CYP2C9 and CFHR3 are significantly down-regulated. Here, SPP1 is linked to hepatocellular carcinoma.