EPCAM and neoplasm: One study showed that epithelial cell adhesion molecules were downregulated by 5-fluorouracil (5FU) in human HCC cell lines (HepG2, Hep3B and HuH-7) and upregulated by cisplatin in the HuH-7 cells, indicating that these molecules are targets of chemoresistance (51) and play an important role in tumor recurrence and progression.