SASP is a well-investigated property of senescence generally considered to be pro-tumorigenic, as senescent tumor cells have specific secretory phenotypes marked by increased secretion of pro-inflammatory (but not anti-tumor immunity), bioactive molecules including IL-6, IL-1a, chemokines (CXCL8), VEGF, and proteases (49). This evidence concerns the gene CXCL8 and neoplasm.