PNPLA3 and steatosis: We found that dietary niacin showed a trend of reduction in patients carrying the PNPLA3 at-risk G allele and BMI ≥ 30 kg/m2 (Figure 1E) whereas by stratifying patients according to the presence of severe steatosis the lower levels of niacin in subjects with the PNPLA3 CG/GG mutation didn’t vary across BMI (Figure 1F).