PNPLA3 and obesity due to melanocortin 4 receptor deficiency: In this cohort, steatosis ≥ 2 was diagnosed in 232/358 patients (64.80%), whereas obesity (BMI ≥ 30 kg/m2) and the PNPLA3 I148M variant were identified in 194/358 (54.18%) and 255/358 (71.2%), respectively (Supplementary Table 4).