This effect was highly emphasized in the subcategory of patients with steatosis ≥ 2 (p = 0.04 at ANOVA, adj p = 0.03 vs steatosis ≥ 2 with BMI < 30 CC, Figure 1H), probably due to the additive weight of PNPLA3 I148M variant and obesity in niacin absorption. Here, PNPLA3 is linked to obesity due to melanocortin 4 receptor deficiency.