Moreover, serum niacin levels were decreased in presence of both obesity and the PNPLA3 G risk allele, thereby resembling what observed in the Discovery cohort although we didn’t observe any variance between patients with steatosis < 2 and ≥ 2 (p = 0.004 at ANOVA, adj p < 0.05 vs PNPLA3 CG/GG with/without obesity and vs PNPLA3 CC with BMI ≥ 30, Figure 2C). Here, PNPLA3 is linked to obesity due to melanocortin 4 receptor deficiency.