CXCL8 and steatosis: In HepG2 cells treated with palmitic acid (PA) to mimic steatosis, niacin supplementation reduced the expression of acyl-CoA diacylglycerol acyltransferase 2 (DGAT2) responsible for the committing step of TG synthesis, the production of ROS and inflammation by inhibiting interleukin-8 (IL-8) (20).