This, indeed, was validated by the findings from the study by Yu et al. Initially, Yu et al. verified that STING was highly expressed in liver Kupffer cells and was nearly undetectable in hepatocytes of WT mice while showing that global STING disruption protected mice from either high-fat die (HFD)-induced NAFLD or methionine- and choline-deficient diet (MCD)-induced NASH. Here, STING1 is linked to metabolic dysfunction-associated steatotic liver disease.