Notably, using various mouse models involving adoptive transfer of STING-disrupted bone marrow cells to lethally irradiated WT mice or adoptive transfer of WT bone marrow cells to lethally irradiated STING-disrupted mice, the study by Luo et al. validated a deleterious role for STING-driven macrophage activation in promoting hepatic steatosis and inflammation, as well as liver fibrosis. Here, STING1 is linked to fatty liver disease.