To be noted, since the first study addressing STING promotion of NAFLD by Luo et al., a significant number of new studies have confirmed the importance of STING in NAFLD or NASH pathogenesis, as well as liver inflammation and related injuries (11–15), and provided novel insights into STING activation in macrophages, which are highlighted below. This evidence concerns the gene STING1 and metabolic dysfunction-associated steatotic liver disease.