Pesticide-induced cognitive impairment is also accompanied by the regulation of NMDAR, PI3K/Akt, MAPK, Keap1/Nrf2/ARE, NF-κB, and other multiple learning and memory pathways, which can be formed into an organic whole through the crosslinking targets such as RAS, Akt, and IKK. Here, AKT1 is linked to Cognitive impairment.