It was found that exercise training promotes the expression of PGC-1α and the transformation of spinal cord injury patients' muscle fibers from fatigue-prone fast muscle fibers to more endurance-prone slow muscle fibers, while improving muscle endurance (111).Therefore, PGC-1α plays a vital role in the repair of nerve and skeletal muscle structure and function after SCI. This evidence concerns the gene PPARGC1A and spinal cord injury.