In 2016, WHO released the CNS tumor classification, dividing MB into four main molecular subtypes: wingless-type mouse mammary tumor virus integration site (WNT), sonic hedgehog [SHH; tumor protein P53 (TP53) mutant and TP53 wild-type], group 3, and group 4 [6, 7]. This evidence concerns the gene SHH and central nervous system neoplasm.