TGF-β causes immunosuppression by acting on macrophages, tilting their function to favor tumor growth, and promoting their ability to release other immunosuppressive cytokines, such as interleukin-10 (IL-10) [41, 42]; it also inhibits DC function [43], curbs T cell responses [44] and inhibits NK cells [45–47]. This evidence concerns the gene IL10 and neoplasm.