A dysregulated immune and particularly IFN-response upon infection has been shown in asthmatic patients (Contoli et al., 2006; Edwards et al., 2013; Zhu et al., 2019; Jackson and Gern, 2022; Liew et al., 2022), but remains controversial (Baraldo et al., 2012; Sykes et al., 2014; Da Silva et al., 2017; Hansel et al., 2017; Sopel et al., 2017; Jazaeri et al., 2021; Yang et al., 2021). This evidence concerns the gene IFNA1 and infection.