Timeline latency between acute viral symptoms and neuro-ophthalmic manifestation, auto-antibody formation, and good response to steroid therapy favor an immune-mediated mechanism.[49] Guillain-Barré, Miller Fisher syndrome, NMO, MOG-associated disease, ADEM, tonic pupil, rhombencephalitis, Bickerstaff encephalitis, myasthenia gravis (MG), and OMAS were all postulated to have delayed-immune mediated mechanisms related to COVID-19. The gene discussed is MOG; the disease is COVID-19.