Optic neuritis has been reported in association with COVID-19 infections in multiple cases where no other etiologies have been determined.[5,14,31,32,33] COVID-19 has also been the harbinger to optic neuritis in NMO spectrum disorder[4,17] and MOG-related disease.[3,18,19,21,63,64] Optic neuritis in association with COVID-19 infection has also been reported in the pediatric age group even in the context of demyelinating conditions.[65] COVID-19-related optic neuritis had a good response to intravenous (IV) corticosteroid therapy in all cases except four.[5,14,22,32]. The gene discussed is MOG; the disease is COVID-19.