CASP1 and columnar cell hyperplasia of the breast: In animal models of CCH, the activation of NLRP3 and AIM2 inflammasome and activation of the pathway of caspase-1/GSDMD mediated canonical pyroptosis pathway were observed, which was considered the most common cause of neurological impairments (Matsuyama et al., 2020; Poh et al., 2021a, b).