In a BCAS mouse model, Poh et al. (2021a) observed the inflammasomes in the cerebral cortex, hippocampus, and striatum following CCH, and found increased expression and activation of NLRP3 and AIM2 inflammasome receptors, especially in the hippocampal region (Matsuyama et al., 2020). Here, NLRP3 is linked to columnar cell hyperplasia of the breast.