In animal models of CCH, the activation of NLRP3 and AIM2 inflammasome and activation of the pathway of caspase-1/GSDMD mediated canonical pyroptosis pathway were observed, which was considered the most common cause of neurological impairments (Matsuyama et al., 2020; Poh et al., 2021a, b). The gene discussed is NLRP3; the disease is columnar cell hyperplasia of the breast.