ACE and hypertensive disorder: In a study of 182 never-treated patients diagnosed with primary HTN, three years of treatment with an angiotensin-converting enzyme inhibitor, an angiotensin receptor blocker (ARB), and/or other antihypertensive agents as needed for BP control, biochemical and echocardiographic evaluations showed significant reductions in left ventricular mass index which were correlated with the decrements in plasma aldosterone and SBP, and increments in urinary sodium excretion [34].