HTN: hypertension; SBP: systolic blood pressure; DBP: diastolic blood pressure; QD: once per day; BID: twice per day; Tx: treatment; ACTH: adrenocorticotrophic hormone; AE: adverse event; CASP: critical appraisal skills program; ASI: aldosterone synthase inhibitor. The gene discussed is CYP11B2; the disease is Hypertension.