IGHE and asthma: A systematic review and meta-analysis were performed to examine two critical outcomes of omalizumab therapy, asthma exacerbation rate, the reduction of the use of inhaled corticosteroids (ICS), and the improvement of the lung function as a secondary outcome using the following keywords in the MEDLINE database: “anti-IgE, severe asthma, children, and randomized controlled trial.” We specifically selected papers that included moderate-to-severe asthma patients and collected data on children and adolescents.