PSEN1 and neurodegenerative disease: Through these proteomic analyses, multiple proteins were identified as being significantly downregulated in the APP/PS1 + eGFP mice, that were augmented via ADAM17 re-expression, including numerous proteins that have been studied in relation to neurodegenerative diseases, such as Septin, Ankyrin-2 (Ank2), and Moesin (Msn), among others (Figure 8C).