cAMP response element-binding protein (CREB) transcription factor is a positive regulator of YAP1 transcription (Zhang et al., 2012; Wang et al., 2013; Muranen et al., 2016) and an integrin alpha 5 (ITGA5)/FAK/CREB signaling axis was described to enhance YAP1 transcription in breast cancer (Zhang et al., 2020). Here, PTK2 is linked to breast cancer.