We further show that cancer cells in direct interaction with fibroblasts undergo transcriptional changes and display a hybrid E/M phenotype in which cells maintain high E-cadherin expression while at the same time upregulating several EMT-TFs and EMT markers (such as ZEB1, ZEB2, TWIST2, vimentin, fibronectin) (Figure 4). The gene discussed is ZEB1; the disease is cancer.