Indeed, although rarer than the other SCLC subpopulations driven by ASCL1, NEUROD1, and POU2F3 (Rudin et al., 2019), the YAP1 subpopulation is nontheless an aggressive SCLC subpopulation (Pearsall et al., 2020). This evidence concerns the gene ASCL1 and small cell lung carcinoma.