Indeed, although rarer than the other SCLC subpopulations driven by ASCL1, NEUROD1, and POU2F3 (Rudin et al., 2019), the YAP1 subpopulation is nontheless an aggressive SCLC subpopulation (Pearsall et al., 2020). The gene discussed is POU2F3; the disease is small cell lung carcinoma.