This strategy proved to be useful for the identification of inhibitors of LexA auto-proteolysis (Barreto et al., 2009) and of the kinase ABL1 (Bharathikumar et al., 2013), involved in bacterial SOS response and chronic myelogenous leukaemia. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.