TNF and COVID-19: Pooled analysis of 3 large international registries SECURE-IBD, GRA and PsoProtect identified old age, number of comorbidities, use of systemic steroids, thiopurines or combination of anti-TNF with a thiopurine (but not anti-TNF monotherapy), methotrexate, rituximab and JAKi as risk factors for severe COVID19 (36, 46–51).