It was found that COS could promote the expression of anti-inflammatory factors TGF-β1 and IL-10 in ovarian GCs of PCOS patients by culturing GCs from PCOS patients and control patients at the optimal concentration and time, Inhibited the expression of pro-inflammatory factors TNFα, IL-6, oxidative stress related factors HIF-1α and VEGFA, and decreased the level of reactive oxygen species. This evidence concerns the gene TNF and polycystic ovary syndrome.