High expression of RAB22A in HCC was positively associated with tumor status (tumor-free vs. with tumor, p = 0.033), sex (female vs. male, p = 0.047), weight (≤ 70 vs. > 70, p = 0.012), and histological grade (grades 3 and 4 vs. grades 1 and 2, p = 0.031). Here, RAB22A is linked to hepatocellular carcinoma.