Logistic regression analysis showed that the increased expression of RAB22A in HCC was significantly correlated with sex (OR = 0.627 for male vs. female, p = 0.036), weight (OR = 0.567 for weight > 70kg vs. ≤ 70kg, p = 0.009), histological grades (OR=1.611 for G3 and G4 vs G1 and G2, p = 0.028), and tumor status (OR = 1.619 for with tumors vs. tumor free, p = 0.026). This evidence concerns the gene RAB22A and hepatocellular carcinoma.