Ligand (IL-4 or IL-13) binding to IL-4Rα and IL-13Rα1 correlate with the differentiation of naïve T cells into Th2 effector cells [the major contributor to B-cell help and IgE antibody production (116)] and eosinophil cells, which are highly related to some autoimmune diseases, including asthma (117) and multiple sclerosis patients (118). The gene discussed is IL4; the disease is autoimmune disease.