KMT2D and gastric cancer: Furthermore, next-generation sequencing analysis identified five frequently mutated protein-coding genes in HBV-infected gastric cancer samples [histone-lysine N-methyltransferase 2B (KMT2B), histone-lysine N-methyltransferase 2D (KMT2D), sex-determining region Y box protein 1 (SOX1), fibroblast growth factor 12 (FGF12), and tubulin beta-2B chain (TUBB2B)] (90).