The percent of lung affected (Figure 3G), the number of “granulomas” or inflammatory cell aggregates (Figure 3H), the extent of alveolar infiltration (Figures 3I, J) and necrosis (Figure 3K), the neutrophil score (Figure 3L), perivascular infiltration (Figure 3M), vasculitis (Figure 3N), interstitial pneumonia (Figure 3O), and pleuritis (Figure 3P) were all not different between Duox1 KO and WT mice on any of the days assessed (1, 30, 90 day(s) post-infection). This evidence concerns the gene DUOX1 and Pleuritis.