First, Duox1 KO mice showed significantly higher levels of certain cytokines/chemokines in the BAL fluid at 30 days post-infection as evidenced by higher concentrations of TNF-α, IL6, KC, CCL3, CCL2, CCL20, CXCL11, CCL11, CCL27, CXCL5, CXCL12, and CCL5. The gene discussed is CXCL12; the disease is infection.