TTN and cancer: In our present study, the most frequent somatic mutations in the LMRG high-risk group were CTNNB1, TTN, TP53, ALB, MUC16, and PCLO. Previous studies have shown that TP53, MUC16, and TTN mutations are common in many types of cancer, including gastric cancer and pancreatic and bladder cancers, and are associated with poor prognoses (35–38).