There seem to be a gradient of maturity among the different subsets where CD73+CD80+PD-L2+ are most mature and this is in line with their capacity to form antibody-secreting cells, whereas CD80-PD-L2- (CD73+/-), which are also much less mutated, may re-enter the GC upon secondary infection/immunisation (12). The gene discussed is PDCD1LG2; the disease is infection.